Efficacy of antibody-based therapies against Middle East respiratory syndrome coronavirus (MERS-CoV) in common marmosets
Identifieur interne : 000E12 ( Main/Exploration ); précédent : 000E11; suivant : 000E13Efficacy of antibody-based therapies against Middle East respiratory syndrome coronavirus (MERS-CoV) in common marmosets
Auteurs : Neeltje Van Doremalen [États-Unis] ; Darryl Falzarano [États-Unis] ; Tianlei Ying [États-Unis] ; Emmie De Wit [États-Unis] ; Trenton Bushmaker [États-Unis] ; Friederike Feldmann [États-Unis] ; Atsushi Okumura [États-Unis] ; Yanping Wang [États-Unis] ; Dana P. Scott [États-Unis] ; Patrick W. Hanley [États-Unis] ; Heinz Feldmann [États-Unis] ; Dimiter S. Dimitrov [États-Unis] ; Vincent J. Munster [États-Unis]Source :
- Antiviral Research [ 0166-3542 ] ; 2017.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (immunologie), Anticorps antiviraux (usage thérapeutique), Anticorps monoclonaux (usage thérapeutique), Appareil respiratoire (anatomopathologie), Appareil respiratoire (imagerie diagnostique), Appareil respiratoire (virologie), Callithrix (virologie), Charge virale (), Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité), Femelle, Immunisation passive (), Immunisation passive (médecine vétérinaire), Immunohistochimie, Infections à coronavirus (médecine vétérinaire), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Lignée cellulaire, Maladies des singes (anatomopathologie), Maladies des singes (traitement médicamenteux), Maladies des singes (virologie), Modèles animaux de maladie humaine, Mâle, Poumon (anatomopathologie), Poumon (imagerie diagnostique), Poumon (virologie), Radiographie.
- MESH :
- anatomopathologie : Appareil respiratoire, Maladies des singes, Poumon.
- imagerie diagnostique : Appareil respiratoire, Poumon.
- immunologie : Anticorps antiviraux.
- médecine vétérinaire : Immunisation passive, Infections à coronavirus.
- pathogénicité : Coronavirus du syndrome respiratoire du Moyen-Orient.
- traitement médicamenteux : Infections à coronavirus, Maladies des singes.
- usage thérapeutique : Anticorps antiviraux, Anticorps monoclonaux.
- virologie : Appareil respiratoire, Callithrix, Infections à coronavirus, Maladies des singes, Poumon.
- Animaux, Charge virale, Femelle, Immunisation passive, Immunohistochimie, Lignée cellulaire, Modèles animaux de maladie humaine, Mâle, Radiographie.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal (therapeutic use), Antibodies, Viral (immunology), Antibodies, Viral (therapeutic use), Callithrix (virology), Cell Line, Coronavirus Infections (drug therapy), Coronavirus Infections (veterinary), Coronavirus Infections (virology), Disease Models, Animal, Female, Immunization, Passive (methods), Immunization, Passive (veterinary), Immunohistochemistry, Lung (diagnostic imaging), Lung (pathology), Lung (virology), Male, Middle East Respiratory Syndrome Coronavirus (pathogenicity), Monkey Diseases (drug therapy), Monkey Diseases (pathology), Monkey Diseases (virology), Radiography, Respiratory System (diagnostic imaging), Respiratory System (pathology), Respiratory System (virology), Viral Load (drug effects).
- MESH :
- chemical , immunology : Antibodies, Viral.
- chemical , therapeutic use : Antibodies, Monoclonal, Antibodies, Viral.
- diagnostic imaging : Lung, Respiratory System.
- drug effects : Viral Load.
- drug therapy : Coronavirus Infections, Monkey Diseases.
- methods : Immunization, Passive.
- pathogenicity : Middle East Respiratory Syndrome Coronavirus.
- pathology : Lung, Monkey Diseases, Respiratory System.
- veterinary : Coronavirus Infections, Immunization, Passive.
- virology : Callithrix, Coronavirus Infections, Lung, Monkey Diseases, Respiratory System.
- Animals, Cell Line, Disease Models, Animal, Female, Immunohistochemistry, Male, Radiography.
Abstract
Cases of Middle East respiratory syndrome coronavirus (MERS-CoV) continue to be identified and with a lack of effective clinical treatment and no preventative strategies, treatment using convalescent plasma or monoclonal antibodies (mAbs) is a potential quick route to an intervention. Passive immunotherapy via either convalescent plasma or mAbs has proven to be effective for other infectious agents. Following infection with MERS-CoV, common marmosets were treated with high titer hyperimmune plasma or the mAb m336, at 6 and 48 h post inoculation. Both treatments reduced signs of clinical disease, but reduction in viral loads in the respiratory tract were only found in the hyperimmune plasma group. A decrease in gross pathology was found only in the mAb-treated group, but no histological differences were observed between treated and control animals. While both hyperimmune plasma and the m336 treatments reduced the severity of disease in the common marmoset, neither treatment resulted in full protection against disease.
Url:
DOI: 10.1016/j.antiviral.2017.03.025
PubMed: 28389142
PubMed Central: 6957253
Affiliations:
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Le document en format XML
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USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Virus Ecology Unit, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT</wicri:regionArea><placeName><region type="state">Montana</region></placeName></affiliation></author><author><name sortKey="Falzarano, Darryl" sort="Falzarano, Darryl" uniqKey="Falzarano D" first="Darryl" last="Falzarano">Darryl Falzarano</name><affiliation wicri:level="2"><nlm:aff id="aff2">Disease Modeling and Transmission, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Disease Modeling and Transmission, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT</wicri:regionArea><placeName><region type="state">Montana</region></placeName></affiliation></author><author><name sortKey="Ying, Tianlei" sort="Ying, Tianlei" uniqKey="Ying T" first="Tianlei" last="Ying">Tianlei Ying</name><affiliation wicri:level="2"><nlm:aff id="aff3">Protein Interactions Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Protein Interactions Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="De Wit, Emmie" sort="De Wit, Emmie" uniqKey="De Wit E" first="Emmie" last="De Wit">Emmie De Wit</name><affiliation wicri:level="2"><nlm:aff id="aff2">Disease Modeling and Transmission, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Disease Modeling and Transmission, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT</wicri:regionArea><placeName><region type="state">Montana</region></placeName></affiliation></author><author><name sortKey="Bushmaker, Trenton" sort="Bushmaker, Trenton" uniqKey="Bushmaker T" first="Trenton" last="Bushmaker">Trenton Bushmaker</name><affiliation wicri:level="2"><nlm:aff id="aff1">Virus Ecology Unit, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Virus Ecology Unit, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT</wicri:regionArea><placeName><region type="state">Montana</region></placeName></affiliation></author><author><name sortKey="Feldmann, Friederike" sort="Feldmann, Friederike" uniqKey="Feldmann F" first="Friederike" last="Feldmann">Friederike Feldmann</name><affiliation wicri:level="2"><nlm:aff id="aff4">Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT</wicri:regionArea><placeName><region type="state">Montana</region></placeName></affiliation></author><author><name sortKey="Okumura, Atsushi" sort="Okumura, Atsushi" uniqKey="Okumura A" first="Atsushi" last="Okumura">Atsushi Okumura</name><affiliation wicri:level="2"><nlm:aff id="aff2">Disease Modeling and Transmission, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Disease Modeling and Transmission, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT</wicri:regionArea><placeName><region type="state">Montana</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff5">Department of Microbiology, University of Washington, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Wang, Yanping" sort="Wang, Yanping" uniqKey="Wang Y" first="Yanping" last="Wang">Yanping Wang</name><affiliation wicri:level="2"><nlm:aff id="aff3">Protein Interactions Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Protein Interactions Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Scott, Dana P" sort="Scott, Dana P" uniqKey="Scott D" first="Dana P." last="Scott">Dana P. Scott</name><affiliation wicri:level="2"><nlm:aff id="aff4">Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT</wicri:regionArea><placeName><region type="state">Montana</region></placeName></affiliation></author><author><name sortKey="Hanley, Patrick W" sort="Hanley, Patrick W" uniqKey="Hanley P" first="Patrick W." last="Hanley">Patrick W. Hanley</name><affiliation wicri:level="2"><nlm:aff id="aff4">Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT</wicri:regionArea><placeName><region type="state">Montana</region></placeName></affiliation></author><author><name sortKey="Feldmann, Heinz" sort="Feldmann, Heinz" uniqKey="Feldmann H" first="Heinz" last="Feldmann">Heinz Feldmann</name><affiliation wicri:level="2"><nlm:aff id="aff2">Disease Modeling and Transmission, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Disease Modeling and Transmission, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT</wicri:regionArea><placeName><region type="state">Montana</region></placeName></affiliation></author><author><name sortKey="Dimitrov, Dimiter S" sort="Dimitrov, Dimiter S" uniqKey="Dimitrov D" first="Dimiter S." last="Dimitrov">Dimiter S. Dimitrov</name><affiliation wicri:level="2"><nlm:aff id="aff3">Protein Interactions Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Protein Interactions Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Munster, Vincent J" sort="Munster, Vincent J" uniqKey="Munster V" first="Vincent J." last="Munster">Vincent J. Munster</name><affiliation wicri:level="2"><nlm:aff id="aff1">Virus Ecology Unit, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Virus Ecology Unit, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT</wicri:regionArea><placeName><region type="state">Montana</region></placeName></affiliation></author></analytic><series><title level="j">Antiviral Research</title><idno type="ISSN">0166-3542</idno><idno type="eISSN">1872-9096</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Monoclonal (therapeutic use)</term><term>Antibodies, Viral (immunology)</term><term>Antibodies, Viral (therapeutic use)</term><term>Callithrix (virology)</term><term>Cell Line</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (veterinary)</term><term>Coronavirus Infections (virology)</term><term>Disease Models, Animal</term><term>Female</term><term>Immunization, Passive (methods)</term><term>Immunization, Passive (veterinary)</term><term>Immunohistochemistry</term><term>Lung (diagnostic imaging)</term><term>Lung (pathology)</term><term>Lung (virology)</term><term>Male</term><term>Middle East Respiratory Syndrome Coronavirus (pathogenicity)</term><term>Monkey Diseases (drug therapy)</term><term>Monkey Diseases (pathology)</term><term>Monkey Diseases (virology)</term><term>Radiography</term><term>Respiratory System (diagnostic imaging)</term><term>Respiratory System (pathology)</term><term>Respiratory System (virology)</term><term>Viral Load (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (immunologie)</term><term>Anticorps antiviraux (usage thérapeutique)</term><term>Anticorps monoclonaux (usage thérapeutique)</term><term>Appareil respiratoire (anatomopathologie)</term><term>Appareil respiratoire (imagerie diagnostique)</term><term>Appareil respiratoire (virologie)</term><term>Callithrix (virologie)</term><term>Charge virale ()</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité)</term><term>Femelle</term><term>Immunisation passive ()</term><term>Immunisation passive (médecine vétérinaire)</term><term>Immunohistochimie</term><term>Infections à coronavirus (médecine vétérinaire)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Infections à coronavirus (virologie)</term><term>Lignée cellulaire</term><term>Maladies des singes (anatomopathologie)</term><term>Maladies des singes (traitement médicamenteux)</term><term>Maladies des singes (virologie)</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Poumon (anatomopathologie)</term><term>Poumon (imagerie diagnostique)</term><term>Poumon (virologie)</term><term>Radiographie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Appareil respiratoire</term><term>Maladies des singes</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Lung</term><term>Respiratory System</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Viral Load</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Monkey Diseases</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Appareil respiratoire</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunization, Passive</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Immunisation passive</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term><term>Monkey Diseases</term><term>Respiratory System</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term><term>Maladies des singes</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps monoclonaux</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Coronavirus Infections</term><term>Immunization, Passive</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Appareil respiratoire</term><term>Callithrix</term><term>Infections à coronavirus</term><term>Maladies des singes</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Callithrix</term><term>Coronavirus Infections</term><term>Lung</term><term>Monkey Diseases</term><term>Respiratory System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Disease Models, Animal</term><term>Female</term><term>Immunohistochemistry</term><term>Male</term><term>Radiography</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Charge virale</term><term>Femelle</term><term>Immunisation passive</term><term>Immunohistochimie</term><term>Lignée cellulaire</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Radiographie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Cases of Middle East respiratory syndrome coronavirus (MERS-CoV) continue to be identified and with a lack of effective clinical treatment and no preventative strategies, treatment using convalescent plasma or monoclonal antibodies (mAbs) is a potential quick route to an intervention. Passive immunotherapy via either convalescent plasma or mAbs has proven to be effective for other infectious agents. Following infection with MERS-CoV, common marmosets were treated with high titer hyperimmune plasma or the mAb m336, at 6 and 48 h post inoculation. Both treatments reduced signs of clinical disease, but reduction in viral loads in the respiratory tract were only found in the hyperimmune plasma group. A decrease in gross pathology was found only in the mAb-treated group, but no histological differences were observed between treated and control animals. While both hyperimmune plasma and the m336 treatments reduced the severity of disease in the common marmoset, neither treatment resulted in full protection against disease.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Agrawal, A S" uniqKey="Agrawal A">A.S. Agrawal</name></author><author><name sortKey="Ying, T" uniqKey="Ying T">T. 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Dimitrov</name><name sortKey="Falzarano, Darryl" sort="Falzarano, Darryl" uniqKey="Falzarano D" first="Darryl" last="Falzarano">Darryl Falzarano</name><name sortKey="Feldmann, Friederike" sort="Feldmann, Friederike" uniqKey="Feldmann F" first="Friederike" last="Feldmann">Friederike Feldmann</name><name sortKey="Feldmann, Heinz" sort="Feldmann, Heinz" uniqKey="Feldmann H" first="Heinz" last="Feldmann">Heinz Feldmann</name><name sortKey="Hanley, Patrick W" sort="Hanley, Patrick W" uniqKey="Hanley P" first="Patrick W." last="Hanley">Patrick W. Hanley</name><name sortKey="Munster, Vincent J" sort="Munster, Vincent J" uniqKey="Munster V" first="Vincent J." last="Munster">Vincent J. Munster</name><name sortKey="Okumura, Atsushi" sort="Okumura, Atsushi" uniqKey="Okumura A" first="Atsushi" last="Okumura">Atsushi Okumura</name><name sortKey="Okumura, Atsushi" sort="Okumura, Atsushi" uniqKey="Okumura A" first="Atsushi" last="Okumura">Atsushi Okumura</name><name sortKey="Scott, Dana P" sort="Scott, Dana P" uniqKey="Scott D" first="Dana P." last="Scott">Dana P. Scott</name><name sortKey="Wang, Yanping" sort="Wang, Yanping" uniqKey="Wang Y" first="Yanping" last="Wang">Yanping Wang</name><name sortKey="Ying, Tianlei" sort="Ying, Tianlei" uniqKey="Ying T" first="Tianlei" last="Ying">Tianlei Ying</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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